mail: sigmund@silber.com
1968 - 1974
Medical School at the University of Munich (Ludwig-Maximilians-University, LMU)
Medical License for Germany
1970 - 1974
Research Associate
Institute for Experimental Cardiovascular Pharmacology, University of Munich
1974-1975
Internships
1975 - 1982
Residency and Fellowships German Heart Center, Munich (Director: Prof. Dr. med. W. Rudolph)
1982 - 1986
Assistant Professor Department of Internal Medicine, Division of Cardiology, Medizinische Klinik Innenstadt, Ludwig-Maximilians-University (LMU), Munich
1982 - 1986
Director, Nuclear Cardiology, University of Munich
1982 - 1986
Member, Isotope and Formulatory Committee, University of Munich
1982 - 1986
Director, ST-Segment Holter Monitoring Laboratory, University of Munich
1986
PhD-equivalent Thesis, („Habilitation“)
at the Ludwig-Maximilians-University, Munich (Prof. Dr. med. E. Buchborn)
Topic: "Nitrate Tolerance: Induction, Rational Circumvention and
Consequences for a Combination Therapy"
1987 - 1989
1990 - Today
Member of the ESC Task Force for Implementation of the Guidelines for the Management of Heart Attacks
Member of the 3rd Task Force of the ESC for the Prevention of Cardiovascular Diseases
Chairman, Working Group of Interventional Cardiology (DGK)
Chairman, Working Group of Intracoronary Brachytherapy (DGK)
Editorial Board, EuroIntervention Journal
Editorial Board, Clinical Research in Cardiology Journal
Editor of the Bilingual Journal „CCN“ (Cathlab and Cardiovascular News)
Member of the Transsectoral Expert Group "Cardiology" IQTIG (Berlin)
Chairman of the annual 2008 to 2019 Symposium "p-c-i live" in Munich
American Heart Journal
American Journal of Cardiology
American Journal of Medicine
Cardiology Journal
Cardiovascular Revascularization Medicine
Catheterization and Cardiovascular Intervention
Circulation
Clinical Cardiology
Clinical Research in Cardiology (Editorial Board)
Deutsche Medizinische Wochenschrift
Die Nuklearmedizin
Echocardiography
EuroIntervention (Editorial Board)
European Heart Journal
Heart
International Journal of Cardiology (Editorial Board)
JACC
JAMA
Lancet
A.A.C.H.E.N. (Angiotensin-II Antagonist to reduce post Coronary stent Hyperplasia of Endothelial Neointima)
ACUITY (A randomized comparison of bivalirudin vs. heparin and GP IIb/IIIa inhibitors in patients undergoing early invasive management for NSTE-ACS)
BETA-CATH (Beta Cath System Study for brachytherapy of de-novo coronary lesions)
BRIE (Beta Radiation In Europe), Principal Investigator for Germany
CAST (Cardiac Arrythmia Supression Trial)
CHARISMA (Clopidogrel for High Atherothrombotic Risk and Ischaemic Stabilization)
CYPHER (German Registry for prospective Evaluation and Follow-up of Patients after Cypher Stent Implantation)
DaVINCI (Registry for prospective Evaluation and Follow-up of Patients after Vision Stent Implantation)
DES.DE (German Drug-Eluting Stent Registry), Member of the Steering Committee
DETECT (Diabetes Cardiovaskular Risk-Evaluation), Member of the Steering Committee
DUETT (A Novel Vascular Sealing Device for Closure of Percutaneous Arterial Access Sites), Principal Investigator
EBEAT (Electron Beam Computed Tomography assessment of coronary calcification), Member of the Safety/Endpoint Committee (SEC)
ENDEAVOR II (Randomized, controlled trial to Evaluate the AVE ABT-578 Eluting Driver Sten)
EURO HEART SURVEY (A prospective Registry Study of the European Society of Cardiology)
EUROSTAR II (European prospective study of the COSTAR Paclitaxel-Eluting Coronary Stent System as compared to the bare stent), Principal Investigator
EVIDENT (Endovascular Investigation Determining the safety of new Tacrolimus-eluting stent grafts)
EVOLVE-II (Randomized Evaluation of a Novel Bioabsorbable Polymer-Coated, Everolimus-Eluting Coronary Stent), Principal National Investigator
EXPRESS (International Registry for prospective Evaluation of patients after EXPRESS Stent Implantation), Principal Investigator
HEALING II + IIb (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth: Progenitor Endothelial Cells)
IMPULSE (Impact Upon Long lesion Stenting)
ISAR-PROJECT-2 (Clinical Evaluation of on-site coating with two Rapamycin dose regimes)
IST (Intracoronary Radiation Therapy), Principal Investigator
IT Biodegradable Study (The Biodegradable Poly-L-Lactic Acid Igaki-Tamai Coronary Stent), Principal Investigator
LUNAR ROX (Registry for prospective Evaluation of Patients after Lunar Rox Stent Implantation), Principal Investigator
LUSTY (Lunar Stent study), Principal Investigator
MASTER (The MGuard mesh-based Embolic Protection Stent for Acute ST-Elevation Reperfusion Trial), Co-Principal Investigator
MUNICH (Multislice Normal Incidence of Coronary Health), Principal Investigator
NOBORI-1 (Prospective, Randomized, Multi-Center Comparison of the Nobori and Taxus Drug Eluting Stent System), Member of the Steering Committee
NIRTOP ('Fused-Gold' vs. 'Bare' Stainless Steel NIRflex Stents), Member of the Steering Committee
OPEN II (Assessment of the STENTYS Paclitaxel-eluting selfexpanding stent in coronary bifurcation lesions)
PETN (Pentaerythrityltetranitrate Evaluation of Tolerance to Nitrates), Principal Investigator
PLATINUM PLUS (Randomized Multicenter Trial to Assess the Everolimus-Eluting Coronary Stent System), Co-Principal Investigator
RECALL (Heinz Nixdorf Recall Study), Advisory Board
REMEDEE (Randomized Study to Evaluate the Combo Abluminal Sirolimus Coated Bio-Engineered Stent)
RESOLUTE-AC (All-Comers Randomized Comparison of a Zotarolimus-Eluting Stent with an Everolimus-Eluting Stent for PCI), Co-Principal Investigator
REVEAL HPS 3 / TIMI 55 (Randomized Evaluation of Anacetrapib in pats. with established vascular disease for increasing HDL-Cholesterol)
SAFE (A global post-market surveillance for the Dexamethason eluting Stent)
START (Stents and Radiation Therapy)
TAXUS-VI (Randomized, double-blind study to assess paclitaxel-eluting stents in the treatment of longer lesions)
OLYMPIA (Global TAXUS Liberté Registry)
ZOMAXX I (Randomized Evaluation of the Zomaxx ABT 578-eluting stent compared to the Taxus Express Paclitaxel-Eluting Stent)